Oleanz 5mg Tablet 10pcs

✔️ Uses of Oleanz 5mg Tablet

• Schizophrenia
• Bipolar disorder
• Agitation
• Mania

✔️ How does Oleanz 5mg Tablet work?

Olanzapine is an atypical antipsychotic. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts, and behavior.

✔️ Side Effects of Oleanz 5mg Tablet

• Common: Somnolence, weight gain, increased appetite.
• Others: Elevated glucose/triglyceride levels, dizziness, akathisia, Parkinsonism, dyskinesia, orthostatic hypotension, anticholinergic effects (constipation, dry mouth), asthenia, edema, photosensitivity reactions.

✔️ Quick Suggestions:

• Olanzapine works well in schizophrenia and bipolar disorder.
• It is less likely to cause heart and movement problems as compared to other similar medicines.
• It may take 4 to 6 weeks to see full effects on thoughts and mood. Keep taking it as prescribed.
• Use caution while driving or doing anything that requires concentration as Olanzapine can cause dizziness and sleepiness.
• It may increase your weight, blood sugar, and cholesterol. Eat healthy, exercise regularly, and monitor your blood levels regularly.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
• Do not stop taking Olanzapine without talking to your doctor first as it may cause worsening of symptoms.

✔️ Indications:

• Schizophrenia: Treats both positive (delusions, hallucinations, disordered thinking, anger, suspiciousness) and negative symptoms (flattened affect, emotional/social withdrawal, speech poverty).
• Bipolar Disorder: Used for acute manic or mixed episodes, with or without psychotic symptoms, and rapid cycling.

✔️ Pharmacology

• Mechanism of Action: Binds to serotonin (5HT2A/2C, 5HT3, 5HT6), dopamine (D1-D5), cholinergic muscarinic (M1-M5), adrenergic (α1), and histamine (H1) receptors. Effectiveness is likely due to dopamine and serotonin type 2 (5HT2) antagonism.
• Absorption: Rapid absorption after oral intake; peak plasma concentrations in 5-8 hours. Food does not affect absorption.
• Safety: Not carcinogenic, mutagenic, or clastogenic.

✔️ Adult Dose of Oleanz 5mg Tablet

Schizophrenia

• Initial Dose: 5-10 mg/day
• Titration: Increase in increments of 5 mg/day at intervals >1 week
• Maintenance: 10-20 mg/day
• Maximum Dose: 20 mg/day

✔️ Bipolar Mania

• Monotherapy: 10-15 mg/day initially
• Adjunct to Lithium or Valproate: 10 mg/day initially
• Maintenance: 5-20 mg/day
• Maximum Dose: 20 mg/day

✔️ Depression in Bipolar Disorder

• Combination with Fluoxetine: Start with 5 mg in the evening
• Adjustment: Range of 5-12.5 mg/day
• Resistant Depression: May increase up to 20 mg/day

✔️ Hepatic Impairment

Initial Dose: 5 mg/day

✔️ Child Dose of Oleanz 5mg Tablet

Bipolar I Disorder (Manic or Mixed Episodes)

• <13 years: Safety and efficacy not established
• 13-17 years:
  • Initial Dose: 2.5-5 mg/day
  • Target Dosage: 10 mg/day
  • Adjustment: Increments/decrements of 2.5-5 mg
  • Dosage Range: 2.5-20 mg/day

✔️ Schizophrenia

• <13 years: Safety and efficacy not established
• 13-17 years:
  • Initial Dose: 2.5-5 mg/day
  • Target Dosage: 10 mg/day
  • Adjustment: Increments/decrements of 2.5-5 mg
  • Dosage Range: 2.5-20 mg/day

✔️ Renal Dose of Oleanz 5mg Tablet

• Renal Impairment
  • Initial Dose: 5 mg/day

✔️ Interactions

• Dopamine Agonists/Levodopa: Olanzapine may counteract the effects.
• CYP1A2 or Glucuronyl Transferase Inducers: E.g., omeprazole, and rifampicin may enhance olanzapine elimination.
• CYP1A2 Inhibitors: May reduce clearance.
• Carbamazepine: May increase clearance.
• Activated Charcoal: Reduces oral bioavailability by 50-60%.
• Caution: When used with centrally acting medications and alcohol.

✔️ Contraindications

• Known hypersensitivity to olanzapine or its ingredients.
• Risk for narrow-angle glaucoma.

✔️ Pregnancy & Lactation

• Pregnancy: Use only if the benefits outweigh the risks to the fetus. No evidence of teratogenicity.
• Lactation: Not recommended. Should not breastfeed while on olanzapine.

✔️ Precautions & Warnings

• Seizures: Use with caution in individuals with a seizure history.
• Blood Cell Counts Caution in patients with low leukocyte/neutrophil counts or bone marrow depression.
• Hepatic Function: Use cautiously in patients with impaired hepatic function or taking hepatotoxic drugs.
• QT Interval: Caution in patients on QT-prolonging drugs.
• Elderly: Special caution advised.
• Operating Machinery: Patients should avoid operating dangerous machinery, including automobiles.

✔️ Storage Conditions

• Store below 30°C, away from light and moisture.
• Keep out of reach of children.